Table 3.
Mean derived comparison of the single-dose pharmacokinetic parameters in subjects allocated to the twice or three times daily dosing regimen (Study 2; Day 2)
| Ibuprofen | Paracetamol | |||
|---|---|---|---|---|
| Twice daily | Three times daily | Twice daily | Three times daily | |
| n | 26 | 26 | 26 | 26 |
| tmax, hrs | 1.75a | 1.25a | 0.67a | 0.67a |
| Cmax, μg.mL-1 (sd) | 32.53 (6.15) | 36.66 (8.14) | 14.74 (5.76) | 15.86 (4.76) |
| AUC0-t, μg.mL-1.hr (sd) | 128.29 (23.60) | 124.01 (23.35) | 46.98 (12.42) | 47.58 (12.79) |
| AUC0-inf, μg.mL-1.hr (sd) | 130.67 (24.61) | 132.27 (25.54) | 49.23 (12.99) | 52.49 (14.06) |
AUC0-inf: area under the curve calculated by linear trapezoidal rule to the last measurable plasma concentration (Cp) with additional area calculated from Cp/Kel (elimination rate constant); AUC0-t: area under the curve calculated by linear trapexoidal rule to the last measurable plasma concentration; Cmax: maximum plasma concentration; hr(s): hour(s); tmax: time of maximum plasma concentration; t1/2: plasma concentration half life; sd: standard deviation. aMedian values.