Table 4.
Comparison of the mean-derived pharmacokinetic parameters for ibuprofen and paracetamol after administration of the fixed-dose combination tablets, twice or three times daily for 3 days (Study 2; Day 4)
| Ibuprofen | Paracetamol | |||
|---|---|---|---|---|
| Twice daily | Three times daily | Twice daily | Three times daily | |
| n | 26 | 26 | 26 | 26 |
| tmax, hrs | 1.50a | 1.50a | 0.67a | 0.67a |
| Cmax, μg.mL-1 (sd) | 33.4 (6.12) | 33.55 (7.32) | 16.09 (5.14) | 15.87 (5.26) |
| Cmin, μg,mL-1 (sd) | 0.72 (0.42) | 2.64 (1.24) | 0.74 (0.25) | 1.87 (0.79) |
| Cav, μg.mL-1 (sd) | 9.61 (1.96) | 13.69 (2.73) | 4.07 (1.05) | 5.86 (1.68) |
| Fluctuation (sd) | 3.44 (0.65) | 2.26 (0.50) | 3.83 (1.02) | 2.47 (0.83) |
| (Cmax-Cmin)/Cav | ||||
|
Swing (sd) (Cmax-Cmin)/Cmin |
62.47 (40.28) | 14.90 (8.72) | 22.81 (10.05) | 8.73 (4.78) |
|
AUC0-t, μg.mL-1.hr (sd) |
230.73 (47.00) | 328.60 (65.71) | 97.67 (25.13) | 140.80 (40.30) |
|
AUCtau, μg.mL-1.hr (sd) |
118.12 (24.23) | 114.26 (22.77) | 51.72 (12.89) | 50.74 (13.29) |
AUCtau: area under the plasma concentration-time curve for a dosing interval; AUC0-t: area under the curve calculated by linear trapezoidal rule to the last measurable plasma concentration; Cav: average plasma concentration; Cmax: maximum plasma concentration; Cmin: minimum plasma concentration; hr(s): hour(s); tmax: time of maximum plasma concentration; sd: standard deviation. aMedian values.