Table 1.
Gene and protein expression in HU mice and recovery versus control.
| mRNA Vs. control | HU7 | HU14 | HU14+R14 | expressed in |
|---|---|---|---|---|
| AP | ↓ | ↓ | ↓ | growth plate chondrocytes, osteogenic, bone marrow cells |
| OC | ↓ | = | = | growth plate chondrocytes, osteogenic, bone marrow cells |
| MT1-MMP | ↑ | ↑ | = | growth plate chondrocytes, osteogenic, bone marrow cells |
| MMP9 | = | ↓ | = | growth plate chondrocytes, osteogenic, bone marrow cells, macrophages |
| BMP1 | = (ns) | ↓ | = | growth plate chondrocytes, osteogenic, bone marrow cells |
| PCOLCEs | = | ↓ | = (↓distal bone marrow) | growth plate chondrocytes, osteogenic, bone marrow cells |
| CXCR4 | = (ns) | ↑ | = | osteogenic, bone marrow cells |
| Protein vs. control | HU7 | HU14 | HU14+R14 | expressed in |
| OC | ND | ↓ | = | growth plate chondrocytes, osteogenic, bone marrow cells |
| BSP | ↓ | = (↓osteoblasts) | ND | osteogenic, bone marrow cells |
| RECK | ↓ | = | ND | osteogenic cells |
| BMP1 | = (ns) | ↓ | = | growth plate chondrocytes, osteogenic, bone marrow cells |
| Stro1 | ↑ | = | ND | osteogenic, bone marrow cells |
| CXCL12 | ND | ↓ | = (only osteoblasts) | bone marrow cells |
Arrows pointing upwards indicate increase, pointing down indicate decrease of expression related to the corresponding control; = stays for equal to control. ND, not done; ns, not shown in the corresponding figure.