Table 1.
Summary of identified randomised controlled trials
| Study first author (country) year | Study population | Mean age (years) | Vitamin D | Control | Hip Fractures | RR/HR | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Eqv daily dose and type | Mode of admin | 25(OH)D Baseline nmol/L | n | 25(OH)D Baseline nmol/L | Number Vit D/ Control |
||||
| Vitamin D vs. Placebo/No treatment trials | ||||||||||
| Lips [29] (Netherlands) 1996 | Community & limited care residents | 80 | 1291 | 400 IU | oral | 27 | 1287 | 26 | 58/48 | HR |
| D3 | 1.18 (0.81-1.71) | |||||||||
| Meyer [30] (Norway) 2002 | Nursing home residents | 84.7 | 569 | 400 IU | oral | 47 | 575 | 51 | 50/47 | HR |
| D3 | 1.09 (0.73-1.63) | |||||||||
| Trivedi [31] (UK) 2003 | Community Doctors' and GP registry | 74.8 | 1345 | 822 IU | oral | NA | 1341 | 53.4 | 21/24 | HR |
| D3 | 0.85 (0.47-1.53) | |||||||||
| Grant [21] (UK) 2005 | Community residents with previous fracture | 77 | 1343 | 800 IU | oral | 38.0 | 1332 | 38.0 | 47/41 | RR |
| D3 | 1.14 (0.75-1.72) | |||||||||
| Law [32] (UK) 2006 | Residential care and nursing home residents | 85 | 1762 | 1100 IU | oral | 59 | 1955 | NA | 24/20 | RR |
| D2 | 1.36 (0.80-2.34) | |||||||||
| Lyons [22] (UK) 2007 | Residential, nursing homes and sheltered housing residents | 84 | 1725 | 822 IU | oral | NA | 1715 | NA | 112/104 | RR |
| D2 | 1.07 (0.83-1.39) | |||||||||
| Smith [33] (UK) 2007 | Community residents | 79.1 | 4727 | 822 IU | Intra-musc. (IM) | 141.25 | 4713 | 141.25 | 66/44 | HR |
| D2 | 1.49 (1.02-2.18) | |||||||||
| Vitamin D and Calcium vs. Calcium trials | ||||||||||
| Grant [21] (UK) 2005 | Community residents with previous fracture | 77 | 1306 | 800 IU D3 + 1000 mg Calcium(daily) | oral | 38.0 | 1311 | 38.0 | 46/49 | RR |
| 0.94 (0.63-1.40) | ||||||||||
Eqv Equivalent
RR Relative risk
HR Hazard Ratio
IU International Units