Table 1.
Estimates of evolutionary divergence between human CD163A, bovine CD163A and bovine CD163c-α SRCR domains
| HsCD163A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SRCR domain | h | i | j | k | b | c | d | e | d' | ||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |||
| BtCD163A | h | 1 | 0.179 | 0.462 | 0.410 | 0.538 | 0.603 | 0.641 | 0.474 | 0.679 | 0.513 |
| (0.043) | (0.056) | (0.056) | (0.056) | (0.055) | (0.057) | (0.057) | (0.053) | (0.057) | |||
| i | 2 | 0.436 | 0.167 | 0.513 | 0.551 | 0.564 | 0.628 | 0.436 | 0.692 | 0.500 | |
| (0.056) | (0.042) | (0.057) | (0.056) | (0.056) | (0.056) | (0.056) | (0.053) | (0.057) | |||
| j | 3 | 0.372 | 0.500 | 0.115 | 0.590 | 0.628 | 0.615 | 0.449 | 0.705 | 0.500 | |
| (0.055) | (0.057) | (0.036) | (0.056) | (0.055) | (0.056) | (0.056) | (0.052) | (0.057) | |||
| k | 4 | 0.590 | 0.590 | 0.590 | 0.115 | 0.692 | 0.654 | 0.526 | 0.731 | 0.551 | |
| (0.056) | (0.056) | (0.056) | (0.036) | (0.052) | (0.056) | (0.057) | (0.053) | (0.056) | |||
| b | 5 | 0.577 | 0.513 | 0.628 | 0.641 | 0.090 | 0.538 | 0.564 | 0.731 | 0.603 | |
| (0.056) | (0.057) | (0.055) | (0.054) | (0.032) | (0.056) | (0.056) | (0.050) | (0.055) | |||
| c | 6 | 0.590 | 0.628 | 0.615 | 0.679 | 0.526 | 0.167 | 0.577 | 0.782 | 0.577 | |
| (0.056) | (0.057) | (0.056) | (0.053) | (0.057) | (0.042) | (0.056) | (0.047) | (0.056) | |||
| d | 7 | 0.526 | 0.474 | 0.474 | 0.551 | 0.577 | 0.551 | 0.090 | 0.667 | 0.474 | |
| (0.057) | (0.057) | (0.057) | (0.056) | (0.056) | (0.056) | (0.032) | (0.052) | (0.057) | |||
| e | 8 | 0.718 | 0.744 | 0.744 | 0.692 | 0.692 | 0.705 | 0.705 | 0.231 | 0.744 | |
| (0.052) | (0.050) | (0.052) | (0.052) | (0.052) | (0.053) | (0.053) | (0.048) | (0.052) | |||
| d' | 9 | 0.551 | 0.538 | 0.551 | 0.526 | 0.603 | 0.538 | 0.423 | 0.692 | 0.167 | |
| (0.056) | (0.056) | (0.056) | (0.057) | (0.055) | (0.056) | (0.056) | (0.052) | (0.042) | |||
| BtCD163c-α | m | 1 | 0.705 | 0.718 | 0.679 | 0.615 | 0.718 | 0.692 | 0.641 | 0.808 | 0.615 |
| (0.052) | (0.051) | (0.053) | (0.055) | (0.051) | (0.052) | (0.054) | (0.045) | (0.055) | |||
| l | 2 | 0.667 | 0.718 | 0.679 | 0.692 | 0.654 | 0.667 | 0.692 | 0.821 | 0.718 | |
| (0.053) | (0.052) | (0.052) | (0.052) | (0.054) | (0.053) | (0.050) | (0.043) | (0.051) | |||
| b | 3 | 0.577 | 0.564 | 0.641 | 0.590 | 0.449 | 0.577 | 0.538 | 0.731 | 0.551 | |
| (0.056) | (0.056) | (0.054) | (0.056) | (0.056) | (0.056) | (0.056) | (0.050) | (0.056) | |||
| c | 4 | 0.667 | 0.654 | 0.628 | 0.628 | 0.615 | 0.526 | 0.590 | 0.731 | 0.615 | |
| (0.053) | (0.054) | (0.055) | (0.055) | (0.055) | (0.057)0 | (0.056) | (0.050) | (0.055) | |||
| n | 5 | 0.654 | 0.679 | 0.628 | 0.590 | 0.654 | 0.667 | 0.564 | 0.705 | 0.603 | |
| (0.054) | (0.053) | (0.055) | (0.056) | (0.054) | (0.053) | (0.056) | (0.052) | (0.055) | |||
| d | 6 | 0.474 | 0.526 | 0.500 | 0.526 | 0.577 | 0.590 | 0.397 | 0.667 | 0.436 | |
| (0.057) | (0.057) | (0.057) | (0.057) | (0.056) | (0.056) | (0.055) | (0.053) | (0.056) | |||
| e | 7 | 0.628 | 0.667 | 0.679 | 0.654 | 0.679 | 0.744 | 0.641 | 0.603 | 0.679 | |
| (0.055) | (0.052) | (0.054) | (0.055) | (0.053) | (0.049) | (0.055) | (0.055) | (0.053) | |||
| d' | 8 | 0.538 | 0.526 | 0.538 | 0.538 | 0.564 | 0.628 | 0.423 | 0.654 | 0.397 | |
| (0.056) | (0.057) | (0.056) | (0.056) | (0.056) | (0.055) | (0.056) | (0.054) | (0.055) | |||
The number of amino acid differences per site from analysis between sequences is shown. All results are based on the pairwise analysis of 26 sequences. Standard error estimates are shown in parentheses and were obtained by using analytical formulas. Analyses were conducted using the amino p-distance model in MEGA4 [64]. All positions containing gaps and missing data were eliminated from the dataset (complete deletion option). There were a total of 78 positions in the final dataset. Estimates below 0.500 are in boldtype, and values on the diagonal corresponding to a high level of identity between sequences are underlined. SRCR domains are labelled with alphabetical designations as previously defined and by inferring the evolutionary relationships between SRCR domains using the Neighbor-Joining and Bayesian methods [1,65,69].