Table 1.

Top 20 Gene Ontology categories significantly over- or underenriched for hypermethylated genes in colon tumors

GO ID	GO type	GO category	P value, colon	Odds ratio, colon	P value, breast	Odds ratio, breast
Categories overenriched for hypermethylated genes
GO:0004888	MF	Transmembrane receptor activity	4E-16	5.0	2E-04	2.2
GO:0016021	CC	Integral to membrane	3E-15	4.2	2E-03	1.8
GO:0031224	CC	Intrinsic to membrane	3E-15	4.2	2E-03	1.8
GO:0005887	CC	Integral to plasma membrane	5E-15	4.6	2E-03	1.9
GO:0031226	CC	Intrinsic to plasma membrane	8E-15	4.5	3E-03	1.9
GO:0004872	MF	Receptor activity	1E-14	4.3	1E-04	2.1
GO:0044459	CC	Plasma membrane part	2E-14	4.1	2E-03	1.8
GO:0004930	MF	G protein coupled receptor activity	3E-14	6.2
GO:0044425	CC	Membrane part	3E-12	3.5	4E-03	1.7
GO:0007268	BP	Synaptic transmission	3E-11	7.3
GO:0019226	BP	Transmission of nerve impulse	4E-11	6.8
GO:0007186	BP	G protein coupled receptor protein signaling pathway	3E-10	3.9
GO:0005886	CC	Plasma membrane	4E-10	3.1
GO:0007187	BP	G protein signaling, coupled to cyclic nucleotide second messenger	1E-09	7.4
GO:0032501	BP	Multicellular organismal process	1E-09	2.9	1E-06	2.3
Categories underenriched for hypermethylated genes
GO:0005622	CC	Intracellular	6E-13	0.3	3E-07	0.4
GO:0044424	CC	Intracellular part	2E-11	0.3	1E-06	0.4
GO:0044238	BP	Primary metabolic process	5E-11	0.3	1E-03	0.6
GO:0008152	BP	Metabolic process	9E-10	0.3	2E-03	0.6
GO:0043170	BP	Macromolecule metabolic process	1E-09	0.3	2E-03	0.6

BP, biological process; MF, molecular function; CC, cellular compartment.