Table 1.

Characterization and preservation of mouse and human network modules

						P value
Human module	Mouse module	Overlap number*	Overlap P value	Top CTX module	Top CTX module characterization	Human	Mouse	PreservationZ-score
M1h	—	—	—	M17	PvalB+ interneurons	8.1E-148	—	2.86
M2h	—	—	—	M9	Oligodendrocytes	<1E-300	—	5.79
M3h	—	—	—	M15	Astrocytes	8.1E-300	—	0.86
M4h	M4m	163 (34)	2.6E-80	M7	Mitochondria	1.5E-243	1.9E-41	17.21
M5h	M5m	137 (43)	5.5E-41	M7	Mitochondria	1.2E-255	2.5E-57	6.72
M6h	M6m	58 (16)	4.8E-18	M10	Glutamatergic synapse	2.9E-102	3.7E-62	4.19
M7h	—	—	—	M11	Unknown	4.0E-91	—	0.32
M8h	M8m	26 (7)	2.8E-08	M5	Microglia	1.1E-169	1.6E-06‡	2.80
M9h	—	—	—	M19	Unknown	1.6E-19	—	0.42
M10h	M10m	6 (1)	9.9E-04	M4	Microglia	8.6E-120	N/S	4.15
M11h	—	—	—	M16	Neuron	3.5E-278	—	11.73
M12h	M12m	38 (7)	5.7E-18	M2	Ribosome	5.1E-68	4.7E-09	12.84
M13h	M13m	92 (29)	1.6E-25	M16	Neuron	1.1E-160	2.2E-33	2.10
M14h	M14m	200 (61)	2.1E-65	M18	Nucleus†	1.0E-233	1.0E-107	8.90
M15h	M15m	15 (6)	4.2E-02	M19	Unknown	6.1E-151	1.9E-11‡	1.23

Columns 5–7 represent the module from the CTX network in ref. 3 showing the highest overlap with each module in the human network, along with associated characterization. Significance of overlap with the corresponding mouse module is presented in column 8. Column 9 measures module preservation (bolded Z-scores indicate significant preservation). P values are corrected for multiple comparisons.

*The expected number of overlapping genes is presented in parentheses.

^†Module characterization was inferred using other means.

^‡Overlap with a network other than CTX in ref. 3 (M8m = CN network, M15m = CTX95 network).