Fig. 1.

(A) Starting structure of the actin-S1 complex with five actin monomers (AC1–AC5) and S1. The colors in the S1 structure indicate the upper 50-K domain (red), the lower 50-K domain (orange), the remaining parts including the converter and the SH3-domain and the lever arm (yellow) and the two light chains (brown) for the unconstrained MD runs as described in the text. Also shown is the EM density (gray surface). (B) Important segments and loops of S1, which are often referred to in the text. ELC: essential light chain, RLC: regulatory light chain. Generated with Chimera (11).