Fig. 6.

(A) Possible H bonds between S1 (yellow) and AC3 (green) with loop 4, the cardiomyopathy loop, and at the lower part of loop 2. The position of Arg 405 is shown in cyan as van der Waals surface pointing away from actin (see text). (B) Electrostatic interactions between S1 (yellow) and the major S1 binding actin monomer (AC3) in green. The main interacting partners in S1 come from loop 2, loop 4, and the cardiomyopathy loop (CM-Loop). The labels show residue type, residue number, and segment (A for actin, H for S1). Generated with Chimera (11).