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SELEX shows that dmPTB binds pyrimidine-rich sequences. (A) Gel mobility shift assay shows that dmPTB binds with high affinity and specificity. (B) Alignment of dmPTB-selected sequences. Pyrimidine tracts are in uppercase and underlined. (C) Sequence of the PTB binding site in the mammalian α-tropomyosin premRNA intron upstream of exon 3.
