Figure 4.

Vincristine treatment increases survival of NOD/SCID mice, but does not induce remission. Sixteen NOD/SCID mice were engrafted with SEM leukemia cells and treated as described in Figure 2. Mice were euthanized when they displayed overt clinical illness, which included greater than 20% weight loss, lethargy, severe weakness, or inability to reach food or water for 24h. Differences in survival between the PBS- and vincristine-treated mice were determined by log-rank test (P < 0.05).