Appendix A.
Severity of Illness Model to Predict Likelihood of 30-Day Mortality
| Variable | Odds Ratio | 95% CI | |
|---|---|---|---|
| Demographics | |||
| Age | 1.01 | 0.97 | 1.05 |
| Age (quadratic term) | 1.00 | 1.00 | 1.00 |
| Tumor Types | |||
| Sarcoma | 1.42 | 0.53 | 3.80 |
| Lung Cancer | 1.66 | 1.41 | 1.96 |
| Conditions during Admission | |||
| Diagnosis of Candida Infection | 1.22 | 0.94 | 1.58 |
| Diagnosis of Any Infection | 1.13 | 0.97 | 1.33 |
| Diagnosis of Aspergillus | 1.80 | 0.67 | 4.83 |
| Acute Renal Failure Diagnosis | 2.18 | 1.63 | 2.91 |
| Transfused Blood Products, other than RBC or Platelets | 1.84 | 0.93 | 3.66 |
| Comorbidities | |||
| NIDDM | 0.82 | 0.67 | 1.01 |
| Hypertension | 0.88 | 0.76 | 1.01 |
| Renal Failure | 1.20 | 0.91 | 1.56 |
| Cancer History | 2.33 | 1.20 | 4.53 |
| Cancer History: Complex Abdominal Tumor | 1.21 | 0.89 | 1.65 |
| COPD | 1.18 | 1.01 | 1.39 |
| Asthma | 1.02 | 0.71 | 1.46 |
| Weight Loss | 1.24 | 1.00 | 1.55 |
| Pneumonia | 1.41 | 1.16 | 1.70 |
| Allogeneic Stem Cell Transplant Recipient | 1.92 | 0.53 | 6.98 |
| Renal Dysfunction | 1.21 | 0.70 | 2.11 |
| Seizure | 1.79 | 0.67 | 4.80 |
| Unstable Angina | 0.67 | 0.42 | 1.06 |
| Smoking History | 0.80 | 0.60 | 1.09 |
| Paraplegia | 1.61 | 1.07 | 2.43 |
| Thrombocytopenia | 1.86 | 1.56 | 2.23 |
| Key Clinical Findings on Admission | |||
| Hyperglycemia | 1.21 | 1.01 | 1.46 |
| Hypoglyemia | 2.02 | 1.25 | 3.28 |
| Hypercalcemia | 2.81 | 1.58 | 5.00 |
| Hypoalbuminemia | 1.17 | 1.02 | 1.35 |
| Alkalosis | 1.26 | 0.99 | 1.61 |
| Acidosis | 2.05 | 1.49 | 2.80 |
| Elevated Total Bilirubin | 1.44 | 1.21 | 1.72 |
| Elevated Blood Urea Nitrogen | 2.07 | 1.80 | 2.38 |
| Elevated Alkaline Phosphatase | 1.45 | 1.24 | 1.70 |
| Thrombocytopenia | 1.09 | 0.89 | 1.35 |
| WBC < 3,000/mm3 | 0.91 | 0.70 | 1.19 |
| WBC >10,000/mm3 | 0.86 | 0.65 | 1.12 |
| Anemia | 1.00 | 0.87 | 1.15 |
| Coagulopathy | 1.06 | 0.90 | 1.25 |
| Diastolic Blood Pressure > 90 mmHg | 1.10 | 0.94 | 1.30 |
| Systolic Blood Pressure > 140 mmHg | 0.92 | 0.79 | 1.08 |
| Systolic Blood Pressure < 90 mmHg | 1.72 | 1.46 | 2.03 |
| Respirations > 30 breaths per minute | 1.85 | 1.42 | 2.42 |
| Respirations < 16 breaths per minute | 0.57 | 0.49 | 0.65 |
| Pulse > 100 beats per minute | 1.39 | 1.16 | 1.66 |
| Cyanosis on Admission | 0.85 | 0.36 | 2.04 |
| Lesion | 1.08 | 0.93 | 1.25 |
| Bleeding | 0.98 | 0.79 | 1.20 |
| Mass | 1.11 | 0.92 | 1.35 |
| CHF | 1.24 | 0.96 | 1.60 |
| Hemoccult Positive | 1.24 | 0.96 | 1.60 |
| Peripheral Vascular Disease | 0.84 | 0.44 | 1.58 |
| Pneumothorax | 1.42 | 0.87 | 2.30 |
| Malignant Tumor | 1.38 | 1.17 | 1.62 |
| Stridor on Admission | 2.42 | 0.71 | 8.21 |
| Edema on Admission | 1.37 | 1.20 | 1.58 |
| Cardiomyopathy | 0.68 | 0.54 | 0.86 |
| Positive Blood Culture | 0.69 | 0.60 | 0.79 |
| Effusion | 1.60 | 1.37 | 1.87 |
| Evidence of Malnourishment | 1.56 | 1.30 | 1.88 |
| Infection | 0.65 | 0.46 | 0.93 |
| Atrial Dysrhythmia | 1.23 | 0.96 | 1.58 |
| Mental Status Change | 2.57 | 2.19 | 3.00 |
| C statistic | 0.82 | ||
CI = Confidence Interval; RBC = Red Blood Cell; NIDDM = Non-insulin-dependent Diabetes Mellitus; COPD = Chronic Obstructive Pulmonary Disease; WBC = White Blood Count
Note. Key Clinical Findings derive from clinical data abstracted from the medical record for the first three days of the hospitalization.