. Author manuscript; available in PMC: 2011 Aug 1.

Published in final edited form as: Osteoarthritis Cartilage. 2010 May 21;18(8):1008–1011. doi: 10.1016/j.joca.2010.03.018

Table 1.

Non-annualized medial compartment JSN (Mean ± SD, mm) by treatment group: results in varus and non-varus OA knees

	Varus OA Knees (MAA_est <178°)			Non-varus OA Knees (MAA_est ≥178°)

	Doxycycline	Placebo	P^*	Doxycycline	Placebo	P^*
16-mo JSN	0.26 ± 0.39	0.36 ± 0.57	0.230	0.12 ± 0.42	0.21 ± 0.52	0.080
N of knees	37	45	0.230	151	146	0.080
30-mo JSN	0.49 ± 0.64	0.55 ± 0.62	0.448	0.26 ± 0.58	0.42 ± 0.73	0.026
N of knees	35	42	0.448	146	138	0.026

Note: Estimated mechanical-axis angle (MAA_est) was based on measurement of the anatomic-axis angle [12].

From mixed-effect (repeated measures) linear models adjusted for treatment group, baseline knee pain and JSW, visit (interim or closeout), clinical center, treatment group-clinical center interaction and treatment group-visit interaction.