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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Biochem Pharmacol. 2010 May 31;80(6):903–912. doi: 10.1016/j.bcp.2010.05.023

Fig. 5.

Fig. 5

4-OH RA formation in human liver microsomes. Panel (A) is a representative chromatogram from a HLM incubation with RA showing 4-OH RA as the primary metabolite formed in HLMs. Panel (B) shows the 4-OH RA formation rates in forty different HLM samples. 0.2 mg Protein was incubated in the presence of 1 μM total RA for 30 min. Panel (C) depicts the correlation between observed RA clearance in HLMs and predicted RA clearances using supersome kinetic values and liver CYP expression levels. There was a significant correlation between the observed and predicted clearances.