Table 2.
Incidence of VTE in non-osteoporotic women versus untreated osteoporotic patients
| Non-osteoporotic cohort (N = 115,009) | Untreated osteoporotic patients (N = 11,546) | |
|---|---|---|
| Patients with VTE (N) | 767 | 61 |
| Annual incidence (per 1,000 PY) | 3.2 | 5.6 |
| Relative risk (95% CI) | 1.75 (1.09–1.84) | |
| Adjusted model on agea | ||
| HR (SE) | 1.43 (0.13) | |
| 95% CI | 1.10–1.86 | |
| p value | 0.007 | |
| Fully adjusted modelb | ||
| HR (SE) | 1.38 (0.15) | |
| 95% CI | 1.03–1.86 | |
| p value | 0.030 | |
VTE venous thromboembolism (including deep venous thrombosis, pulmonary embolism, or retinal vein thrombosis), CI confidence interval, HR hazard ratio, SE standard error; PY patients–years
aHR between groups based on a Cox proportional hazards regression model adjusted on age
bHR between groups based on a Cox proportional hazards regression model fully adjusted for all confounders described in the Methods section (final regression model by backward selection)