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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Cancer Biol Ther. 2009 Dec 19;8(23):2275–2283. doi: 10.4161/cbt.8.23.10137

Figure 1. Patient tumor-SCID mouse model of head and neck cancer.

Figure 1

The figure depicts the basic workflow algorithm involved in establishing and characterizing patient tumor xenografts in SCID mice. Surgical samples of head and neck squamous cell carcinomas (HNSCC) confirmed by histopathologic assessment were serially passaged in vivo. Engraftments were considered successful when tumors could be established over 2 passages (2p). For experimental studies, 3-5p tumors were utilized. Histologic assessment was performed at all stages of tumor transplantation for comparison between original patient tumors and xenografts. Non-invasive magnetic resonance imaging (MRI) based assessment of tumor vascularity was correlated with immunohistochemistry and tumor growth.