Table 1.

Entry	CD	Ligand		Reaction condition	Product
1a		10–70 equiv	4	60–70 °C, 10 d	7EACD,6
2b	3	8 equiv		rt, 5 h	7
3c		8 equiv		rt, 7 d	8
4c		8 equiv		60–70 °C, 18 h	11
5d		8 equiv	9	60–70 °C, 18 h	S.M recovered
6d		10 equiv	10	60–70 °C, 10 d	S.M recovered
7d	15	21 equiv	4	60–70 °C, 10 d	16
8e	19	1–3 equiv		60–70 °C, 3 d	1EACD,20
9f	17	21 equiv	12	60–70 °C, 7 d	21

^a(1) DMF, 60–70 °C, 10 d, (2) NaBH₄, MeOH, 2 h.

^b(1) rt, 5 h, (2) NaBH₄, MeOH, 2 h.

^c(1) DMF, rt, 7 d, (2) NaBH₄, MeOH, 2 h.

^d(1) DMF, 60–70 °C, 18 h, (2) NaBH₄, MeOH, 2 h.

^e(1) DMF, 60–70 °C, 3 d, (2) NaBH₄, MeOH, 2 h.

^fDMF, 60–70 °C, 7 d.