Skip to main content
. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Chem Biol Drug Des. 2010 May 4;76(1):1–9. doi: 10.1111/j.1747-0285.2010.00986.x

Figure 4.

Figure 4

Specificity of the inhibitors for the EGF receptor. Cells expressing either the insulin receptor or the PDGF receptor were pre-incubated with 1% DMSO (controls) or 100 μM of each of the 20 candidate compounds. A) Insulin receptor kinase activity was assessed by measuring the phosphorylation of IRS-1 in response to 3 nM insulin for 1 minute. The data shown are representative of three separate experiments. B) PDGF receptor kinase activity was assessed by measuring autophosphorylation of the PDGF receptor in response to 2 nM PDGF for 3 minutes. The data shown are representative of two separate experiments.