Table 2.

Demographic information from published papers that studied the role of nitric oxide in the diagnosis (A) and treatment (B) of asthma; healthy reference population values are listed in (C). All papers followed ATS guidelines for online measurement.

First author	Date	n	Flow rate (ml s⁻¹)	Device	Country	Population	Confounders studied
(A)
Warke [59]	2002	71	50	Sievers NOA280	UK	Asthma, children	Atopy, asthma
Kharitonov [51]	2003	59	50	Aerocrine NIOX	UK	Asthma, adults & children	Gender
Malmberg [60]	2003	96	50	EcoPhysics CLD 77AM	Finland	Asthma, children	Treated and probable asthmatics, chronic cough
Olin [61]	2004	228	50	Eco Physics CLD700AL	Sweden	Asthma, adults	Exposure to ozone, atopy, asthma and ICS
Smith [62]	2004	47	50 (& 200)	Unknown	New Zealand	Asthma, adults
Nguyen [63]	2005	44	50	Aerocrine NIOX	USA	Asthma, adults	EBC higher oxides of NO
Smith [64]	2005	52	50	Aerocrine NIOX	New Zealand	Asthma, adults	Smokers not excluded, age, sex
Travers [46]	2007	528	50	Aerocrine NIOX	New Zealand	Healthy, adults	Gender, atopy, smoking status
Kostikas [47]	2008	961	50	MINO	Greece	Asthma, adults	Atopy, smoking

(B)
Beck-Ripp [38]	2002	46	50	Logan LR 2000	Germany	Asthma, children	ICS administration
Berry [15]	2005	566	250	Logan LR 2000	UK	Asthma, adults	Sputum eosinophil, smoking
Pijnenburg [36]	2005	40	50	Sievers NOA280	Netherlands	Asthma, children	Relapse, time after decrease in ICS
Pijnenburg [65]	2005	85	50	Aerocrine NIOX	Netherlands	Asthma, children	ICS doses
Smith [50]	2005	97	250 (50 calculated)	Unknown	New Zealand	Asthma, adults
Spergel [49]	2005	30	50	Sievers NOA280	USA	Asthma, children
Zacharasiewicz [54]	2005	40	50	Aerocrine NIOX	UK	Asthma, children	ICS dose
Fritsch [66]	2006	47	50	Aerocrine NIOX	Austria	Asthma, children	Asthma control, age
Gruffydd-Jones [67]	2007	37	50	Aerocrine NIOX	UK	Asthma, adults & children	Bariatric surgery, BMI, ACT
Maniscalco [68]	2007	22	50	Sievers 280 NOA	Italy	Asthma, adults	Treatment, withdrawal, atopy
Montuschi [69]	2007	14	50	Aerocrine NIOX	Italy	Asthma, children	Asthma severity
Robroeks [70]	2007	114	50	Aerocrine NIOX	Netherlands	Asthma, children	Corticosteroid dose
Shaw [71]	2007	118	50	Not stated	UK	Asthma, adults	Severity of asthma
Michils [48]	2008	341	50	Logan LR200	Belgium	Asthma, adults	Asthma severity, eosinophils, neutrophils, tissue markers
Shannon [72]	2008	50	50	Not stated	Canada	Asthma, adults

(C)
Van der Lee [73]	2002	117	250	Eco Physics CLD 77AM	Netherlands	Healthy, adults	Gender
Buchvald [53]	2005	405	50	Aerocrine NIOX	Denmark	Healthy, children	Age, atopy
Olin [74]	2006	2200	50	Aerocrine NIOX	Sweden	Healthy, adults	Height, age, atopy, smoking status
Olivieri [75]	2006	204	50 (&100, 200)	Ecomedics CLD88	Italy	Healthy, adults	Gende
Olin [40]	2007	3376	50	Aerocrine NIOX	Sweden	Healthy, adults	Age, height, atopy
Stark [76]	2007	21	50	Sievers NOA280	Finland	Healthy, adults	Diurnal, seasonal, day-to-day
Sundy [77]	2007	994	50	Sievers 280i	USA	Healthy, adults	Smoking, age
Zietkowski [78]	2007	26	50	Sievers 280i	Poland	Asthma, adults
Bohadana [42]	2008	39	50	NIOX Aerocrine	France	Healthy, adults	Smoking, gender
Kerckx [79]	2008	21	50	Logan LR200	Belgium	Asthma, adults
Kovesi [45]	2008	657	50	Eco Medics CLD88sp	Canada	Healthy, children	Race, age, height; gestation, exercise, gender, BMI, age, height, FEV1
Levesque [44]	2008	895	50	Sievers 208i	USA	Healthy, adults	Race, Gender, URI, height, weight, BP, IgE, ECP, nitrate

Abbreviations: asthma control test (ACT); blood pressure (BP); body mass index (BMI); eosinophil cationic protein (ECP); inhaled corticosteroids (ICS); upper respiratory infection (URI).