Table 1.

Chemical-genetic analysis of MitoBloCK-1 activity

Strain	MIC50* (μM)	MIC50* (mg/mL)
tim10-1 rho null	0.75 ± 0.02	0.28 ± 0.01
tim10-1	1.00 ± 0.05	0.37 ± 0.03
tim10-73	2.00 ± 0.06	0.74 ± 0.02
tim9-3	11.34 ± 1.56	4.18 ± 0.57
tim23-1	> 200	> 74
TIM10 rho null	12.39 ± 0.9	4.56 ± 0.33
TIM10	> 200	> 74
tim10-1 TIM10	> 200	> 74
tim10-1 tim9S	9.91 ± 0.24	3.65 ± 0.09
tim10-1 TIM9 (2μ)	1.48 ± 0.08	0.54 ± 0.03
tim10ts TIM8 (2μ)	2.42 ± 0.15	0.89 ± 0.05
tim10-1 TIM13 (2μ)	1.26 ± 0.03	0.46 ± 0.01
tim10-1 TIM22 (2μ)	8.35 ± 0.27	3.07 ± 0.1
tim10-1 TIM23 (2μ)	1.37 ± 0.04	0.51 ± 0.02

^*mean ± s.d. (n = 3).