Fig. 1.

Protective efficacy of TLR agonists and IL-15 adjuvanted peptide-primed/rMVA-boosted vaccine regimens. (A) Schedule of intracolorectal immunization protocol. (B) Levels of viral RNA in plasma of the individual animals (denoted by single letters), as well as geometric means of the groups with different immunization protocols following intrarectal challenge with 10 ID₅₀ SIVmac251. *, Mamu-B*17⁺ animals. (C) VL in the colon and spleen were measured at the time of necropsy. Comparisons among groups were performed by two-sided Wilcoxon's rank-sum tests. Bars show mean and SEM of Log₁₀.