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. 2010 May 8;107(21):9614–9619. doi: 10.1073/pnas.0912594107

Fig. 2.

Fig. 2.

P63 mRNA stability is regulated by RNPC1. (A) The level of TA and ΔN p63 transcripts was measured by qRT-PCR in HaCaT cells uninduced or induced to express HA-tagged RNPC1a or RNPC1b for 24 h. The level of GAPDH transcript was measured as an internal control. (B) The experiment was performed as in (A) with MCF7 cells uninduced or induced to knock down RNPC1 for 3 d. (C) p63 mRNA half-life is decreased by RNPC1a. The level of p63 transcript was measured by qRT-PCR in HaCaT cells uninduced or induced to express RNPC1a for 24 h, followed by treatment with actinomycin D for various times. Data were presented as Mean ± S.D. (∗P < 0.05; n = 3 per group). (D) The experiment was performed as in (C) with MCF7 cells uninduced or induced to knock down RNPC1 for 3 d. Data were presented as Mean ± S.D. (∗P < 0.05; n = 3 per group).