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. 2010 May 10;107(21):9771–9776. doi: 10.1073/pnas.1003738107

Fig. 3.

Fig. 3.

AIM2 and ASC form a complex with F. tularensis DNA. (A) Immunofluorescence microscopy of F. novidica U112-infected BMDMs at 5.5 h postinfection. DIC, differential interference contrast. Arrows indicate colocalization of DNA, degraded bacteria, AIM2, and ASC. Asterisks label diffuse AIM2 accumulation with DNA. Images are representative of at least three independent biological replicates. (Scale bar: 10 μm.) (B) BMDMs were infected with F. novidica U112 prelabeled with Hoechst 33342 nucleic acid stain. Arrows and asterisks indicate colocalization of bacterial DNA and AIM2. (Scale bar: 10 μm for Upper; scale bar: 2 μm for Lower.)