Fig. 3.
Evaluation of sulfoxythiocarbamate analog for NQO1 enzyme induction on mouse skin. The back of each SKH-1 hairless mouse (n = 3) was topically treated with three concentrations of 8a (indicated amounts in 40 μL of 80% aq. acetone) and solvent only over ca. 2.5 cm2 area for three doses at 24-h intervals. Mice were euthanized 24 h after the last dose, and dorsal skin was harvested. NQO1 specific activity was measured in supernatant fractions of homogenates of skin sections treated with 8a or solvent (control). Means ± SD are shown.