Table 1.
Genotype, allele, and haplotype frequencies of rs1533428 and rs12994401 in patients with POAG and control subjects
| POAG |
||||||
| SNP | Genotype/allele/haplotype | Control (n = 191) | NTG (n = 213) | P value | HTG (n = 212) | P value |
| rs1533428 | Genotype | |||||
| TT | 30 (15.7) | 34 (16.0) | 33 (15.6) | |||
| CT | 84 (44.0) | 100 (46.9) | 0.79* | 92 (43.4) | 0.99* | |
| CC | 77 (40.3) | 79 (37.1) | 87 (41.0) | |||
| Allele | ||||||
| T | 144 (37.7) | 168 (39.4) | 0.66† | 158 (37.3) | 0.94† | |
| C | 238 (62.3) | 258 (60.6) | 266 (62.7) | |||
| rs12994401 | Genotype | |||||
| TT | 16 (8.4) | 26 (12.2) | 25 (11.8) | |||
| CT | 101 (52.9) | 95 (44.6) | 0.19* | 103 (48.6) | 0.46* | |
| CC | 74 (38.7) | 92 (43.2) | 84 (39.6) | |||
| Allele | ||||||
| T | 133 (34.8) | 147 (34.5) | 0.94† | 153 (36.1) | 0.71† | |
| C | 249 (65.2) | 279 (65.5) | 271 (63.9) | |||
| rs1533428–rs12994401 | Haplotype‡ | |||||
| C-C | 0.41 | 0.41 | 0.39 | |||
| C-T | 0.21 | 0.20 | 0.96* | 0.23 | 0.84* | |
| T-C | 0.24 | 0.24 | 0.25 | |||
| T-T | 0.14 | 0.15 | 0.13 | |||
Data are given as number (percentage) for genotype and allele and as frequency for haplotype.
*χ2 test.
†Fisher exact test.
‡Haplotype frequency was analyzed using expectation maximization algorithm.