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. 2010 May 10;107(21):9677–9682. doi: 10.1073/pnas.1004431107

Fig. 3.

Fig. 3.

Life span studies on wild-type flies with neuron-specific overexpression of Mgat1. (A) Targeted expression of Mgat1 in the CNS of wild-type flies increases Drosophila life span by a relatively small amount. Targeted expression of Mgat1 to the CNS of wild-type flies increases the mean and maximum life spans by 8.8 and 12.7%, respectively, relative to wild-type flies. The genotypes, life spans, and GnT1 activities are shown in Table 1. (B) Wild-type flies overexpressing Mgat1 are resistant to oxidative stress. Resistance to oxidative stress was measured in adult wild-type flies that express a wild-type Mgat1 transgene in the CNS [Mgat1 (+RU)] compared with genetically matched controls that do not express Mgat1 [Mgat1 (−RU)]. Flies were fed normal food containing 3% hydrogen peroxide and their life span was measured over a 180-h period. The Mgat1 expressing flies [Mgat1 (+RU)] lived significantly longer under conditions of oxidative stress than control flies. All life span plots were derived from a single population of flies.