Table 1.
Changes in the sodium, potassium-ATPase (Na+/K+ -ATPase) in different regions of rat brain during PTZ-induced epilepsy and on pretreatment with different extracts of Centella asiatica
| Brain area | SC | PTZ | nHE+PTZ | CE+PTZ | EAE+PTZ | nBE+PTZ | AE+PTZ | F-value |
|---|---|---|---|---|---|---|---|---|
| CC | 4.491 | 3.909* | 6.206* | 4.564 | 4.796 | 7.074* | 3.405* | 83.75 |
| ±0.300 | ±0.467 | ±0.282 | ±0.287 | ±0.196 | ±0.546 | ±0.601 | ||
| (-12.96) | (38.18) | (1.62) | (6.78) | (57.50) | (-24.19) | |||
| CB | 4.929 | 3.876* | 5.779 | 5.141 | 5.135 | 7.117* | 3.502* | 43.46 |
| ±0.189 | ±0.426 | ±0.444 | ±0.495 | ±0.570 | ±0.597 | ±0.132 | ||
| (-21.36) | (17.24) | (4.31) | (4.19) | (44.38) | (-28.94) | |||
| PM | 5.64 | 4.138* | 8.054* | 4.803 | 5.741 | 7.847* | 3.609* | 76.36 |
| ±0.311 | ±0.443 | ±0.449 | ±0.189 | ±0.582 | ±0.524 | ±0.377 | ||
| (-26.64) | (42.79) | (-14.83) | (1.77) | (39.12) | (-36.00) | |||
| HC | 5.273 | 4.384 | 6.729* | 6.206* | 8.736* | 4.679 | 3.933* | 82.73 |
| ±0.609 | ±0.261 | ±0.234 | ±0.282 | ±0.228 | ±0.277 | ±0.519 | ||
| (-16.85) | (27.62) | (17.70) | (65.68) | (-11.26) | (-25.41) |
Values are expressed in μ moles of inorganic phosphate formed/mg protein/h., All the values are mean, ±SD of five individual observations, Values in '()' parentheses are percent change over saline control, Values with
*
are significant at P<0.05 compared to SC in Scheffe test