Table 2.
Changes in the sodium, potassium-ATPase (Na+/K+ -ATPase) in different regions of rat brain during PTZ-induced epilepsy and on pretreatment with different extracts of Centella asiatica
| Brain area | SC | PTZ | nHE+PTZ | CE+PTZ | EAE+PTZ | nBE+PTZ | AE+PTZ | F-value |
|---|---|---|---|---|---|---|---|---|
| CC | 7.771 | 5.039* | 6.152* | 6.210* | 6.531* | 7.719 | 4.646* | 23.41 |
| ±0.220 | ±0.512 | ±0.562 | ±0.463 | ±0.483 | ±0.504 | ±0.341 | ||
| (-35.14) | (-20.82) | (-20.08) | (-15.95) | (-0.65) | (-40.2) | |||
| CB | 6.935 | 5.547* | 9.469* | 6.769 | 6.544 | 5.993* | 4.646* | 123.17 |
| ±0.410 | ±0.375 | ±0.211 | ±0.222 | ±0.439 | ±0.199 | ±0.341 | ||
| (-20.01) | (36.55) | (-2.39) | (-5.62) | (-13.58) | (-32.99) | |||
| PM | 5.122 | 3.652* | 7.501* | 5.602 | 6.673* | 4.542 | 3.255* | 110.99 |
| ±0.687 | ±0.335 | ±0.280 | ±0.382 | ±0.315 | ±0.304 | ±0.275 | ||
| (-28.69) | (46.46) | (9.38) | (30.28) | (-11.31) | (-36.43) | |||
| HC | 6.708 | 4.689* | 5.150* | 5.626* | 8.673* | 6.831 | 4.330* | 78.65 |
| ±0.252 | ±0.646 | ±0.215 | ±0.332 | ±0.282 | ±0.234 | ±0.521 | ||
| (-30.09) | (-23.21) | (-16.12) | (29.30) | (1.83) | (-35.45) |
Values are expressed in μmoles of inorganic phosphate formed/mg protein/h., All the values are mean, ±SD of five individual observations, Values in '()' parentheses are percent change over saline control, Values with
*
are significant at P<0.05 compared to SC in Scheffe test