. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: Pharm Res. 2010 Jan 23;27(3):457–467. doi: 10.1007/s11095-009-0034-9

Table II.

Structures, physicochemical properties, observed absT₅₀, K_a, and predicted absorption profile of nine monocharged molecules^a

Drug name	pK_a	logP	Petitjean radius	abs T₅₀ observed (min)	Ka observed (min⁻¹)	abs T₅₀ (min)	Ka (min⁻¹)	abs T₅₀ in airway (min)	abs T₅₀ in alveolar (min)

						Predicted
Imipramine	9.2	4.01	5	1	0.69	1.12	0.62	1.41	0.62
Talinolol	9.76	2.46	9	17	0.041	1.26	0.55	1.69	0.59
Losartan	8.15^b	4.18	8	26	0.027	2.27	0.30	2.97	1.27
Metoprolol	9.67	1.49	7	2.5	0.28	1.48	0.47	2.10	0.60
Propranolol	9.67	2.5	6	2	0.35	1.25	0.55	1.66	0.59
Barbital	7.58^b	0.74	3	0.93	0.75	2.42	0.29	3.20	1.32
Amitrole	8.59^b	0.31	2	1.3	0.53	2.30	0.30	3.03	1.26
Procainamide	9.04	0.83	6	2.3	0.30	1.63	0.42	2.31	0.68
Erythromycin	8.38	1.22	8	6.3	0.11	1.58	0.44	2.05	0.85

Observed absT₅₀ is from (17, 23, 24). logP and pK_a was calculated by Chemaxon (52). The Petitjean descriptor was calculated by MOE (53, 54).

acid pK_a