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. Author manuscript; available in PMC: 2011 Mar 5.
Published in final edited form as: Cell. 2010 Mar 5;140(5):717–730. doi: 10.1016/j.cell.2010.02.013

Figure 7. Model of lta4h Effects on Eicosanoid Balance.

Figure 7

Variations in LTA4H levels or activity, represented by the rheostat symbol, influence the balance between pro-inflammatory LTB4 and anti-inflammatory LXA4. High levels of LXA4 inhibit TNF production, resulting in exuberant intracellular bacterial growth, increased granuloma formation, increased macrophage death and the cording morphology typical of extracellular mycobacteria. Although WT levels of TNF are protective during infection, excessive levels of TNF may produce increased immunopathology, resulting in worse outcome from mycobacterial infections.