. Author manuscript; available in PMC: 2011 Mar 5.

Published in final edited form as: Cell. 2010 Mar 5;140(5):717–730. doi: 10.1016/j.cell.2010.02.013

Table 1.

Associations of Tuberculosis and Leprosy with Polymorphisms in LTA4H

SNP	Group	N	Genotype frequency			HWE^b	Heterozygosity model

			00^a	01^a	11^a	P value	OR^c	P value	P adj^d

Tuberculosis in Vietnam
rs1978331 T/C	TB	657	0.406	0.397	0.196	<0.0001	0.71	0.002	0.011
rs1978331 T/C	Controls	748	0.350	0.480	0.170	0.83
rs17677715 T/C	TB	640	0.988	0.009	0.003	<0.0001	0.69	0.476	ns
rs17677715 T/C	Controls	741	0.987	0.013	0.000	0.85
rs2247570 A/G	TB	658	0.891	0.093	0.017	<0.0001	0.66	0.017	ns
rs2247570 A/G	Controls	743	0.860	0.133	0.007	0.59
rs2660898 T/G	TB	658	0.353	0.400	0.248	<0.0001	0.64	0.00004	0.0003
rs2660898 T/G	Controls	751	0.277	0.509	0.214	0.56
rs2660845 G/A	TB	645	0.310	0.428	0.262	0.0003	0.84	0.099	ns
rs2660845 G/A	Controls	724	0.314	0.472	0.214	0.22
rs2540475 C/T	TB	660	0.529	0.364	0.108	0.003	0.82	0.068	ns
rs2540475 C/T	Controls	739	0.497	0.411	0.092	0.66

Leprosy in Nepal
rs1978331 T/C	MB w/o ENL^*	436	0.336	0.435	0.229	0.01	0.62	0.001
	MB w/ ENL^*	120	0.258	0.492	0.250	0.81	0.78	0.24
	PB^*	328	0.274	0.555	0.171	0.05
rs2660898 T/G	MB w/o ENL^*	386	0.509	0.372	0.120	0.01	0.7	0.021
	MB w/ ENL^*	113	0.372	0.504	0.124	0.42	1.21	0.38
	PB^*	315	0.466	0.457	0.078	0.18

Multibacillary leprosy (MB) without or with erythema nodosum leprosum (ENL); paucibacillary leprosy (PB)

^a)

For each SNP, 0 represents the allele associated with higher levels of LTB₄ (Figure 6A)

^b)

P values for deviations from Hardy Weinberg Equilibrium (HWE)

^c)

For each SNP, odds ratios (OR) calculated for heterozygosity (01) versus homozygosity (00+11) for cases versus controls

^d)

P values adjusted by Bonferroni correction for multiple tests