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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Biochemistry. 2010 Jun 15;49(23):4804–4812. doi: 10.1021/bi100207k

Figure 6.

Figure 6

Relationships between NaV1.2 rINa versus Kd and volume of ddKIIIA[K7X]'s residue 7. Plots of data in Table 1. Each data point is labeled with amino acid corresponding to residue 7 of ddKIIIA[K7X]. A, rINa versus Kd shows that efficacy and affinity are apparently uncorrelated. B, rINa versus volume of residue 7 shows that rINa varies inversely with size of the residue; remarkably, rINa seems insensitive to side-chain charge or hydrophobicity. AA volumes are from Table 1 of Perkins (38); dap volume was estimated by subtracting the volume of three methylene groups from volume of Lys, where volume of a methylene group was estimated from the average difference in volume between Glu and Asp, and Gln and Asn.