Table 4.
Summary of significant genotype-intermediate phenotype associations
| Entire cohort available | Cohort with intermediate phenotype | Δ Vol | MTV | Solid GE (t1/2) | p-value† | |
|---|---|---|---|---|---|---|
| ADRA2C_Del322_325 | ||||||
| ins/ins | 200 | 52 | 487.9±13.7 | 1247.4 ± 40.8 | 123.5 ± 5.4 | .0271 ↑(Solid GE) |
| ins/del; del/del | 24; 0 | 10; 0 | 486.3±24.8 | 1060.5±113.7 | 101.8±7.5 | .1136 ↓ (MTV) |
| ADRA2A-rs491589 CC | 158 | 46 | 503.1±13.3 | 1207.6±48.2 | 117.7±5.0 | .0395 ↓(ΔVol) |
| CT_TT | 62; 4 | 14;2 | 449.0±23.8 | 1245.0±65.5 | 125.6±12.0 | |
| ADRA2A-rs553668 GG | 157 | 45 | 503.1±13.3 | 1210.8±49.2 | 117.6±5.1 | .0395 ↓ (ΔVol) |
| AG_AA_ | 62; 5 | 15;2 | 449.0±23.8 | 1234.4±62.4 | 125.6±11.2 | |
| ADRA2A-rs3750625 CC | 200 | 55 | 477.6±12.5 | 1216.8±42.0 | 122.7±5.1 | .0275 ↑ (ΔVol) |
| AC_AA | 23; 1 | 7;0 | 559.8±27.5 | 1220.9±121.5 | 94.8±10.1 | |
| ADRA2A-rs34665740 AA | 209 | 57 | 480.9±12.6 | 1223.9±41.8 | 120.5±5.1 | .0900 ↑ (ΔVol) |
| AC_CC | 14; 1 | 5;0 | 547.2±33.6 | 1141.0±113.0 | 109.9±12.8 | |
| UCP_2 +347445bp-insdel | ||||||
| ins/ins | 111 | 31 | 498.5±18.1 | 1217.9±48.5 | 112.1±5.7 | All p>0.15 |
| ins/del; del/del | 98;15 | 28;3 | 475.3±15.7 | 1216.6±62.9 | 126.9±7.5 | |
| UCP_3-rs590336 TT | 62 | 16 | 462.4±17.5 | 1055.3±62.3 | 130.1±11.1 | .0750 ↑ (MTV) |
| CT_ CC | 124;38 | 38;8 | 496.7±15.0 | 1273.6±45.9 | 115.8±5.1 | |
| UCP_3-rs1685356 CC | 69 | 19 | 480.7±17.6 | 1044.3±53.6 | 127.0±10.1 | .0261 ↑ (MTV) |
| CT_ TT | 118;37 | 35; 8 | 491.0±15.9 | 1293.7±47.4 | 116.5±5.3 | |
| UCP_3-rs11235971 TT | 110 | 29 | 513.2±15.9 | 1244.3±55.6 | 115.1±6.5 | .0676 ↓ (ΔVol) |
| CT_ CC | 101;13 | 30;3 | 466.8±16.9 | 1193.1±56.0 | 124.1±7.0 | |
| UCP_3-rs2075577 TT | 73 | 18 | 456.6±16.4 | 1024.4±59.3 | 128.4±10.4 | .0805 ↑ (ΔVol) |
| CT_ TT | 122;29 | 37;7 | 501.3±15.4 | 1296.1±45.1 | 115.9±5.1 | .0058 ↑ (MTV) |
| GNB3-rs2269355 CC | 74 | 26 | 517.2±17.0 | 1196.9±68.2 | 126.7±8.3 | .0212 ↓ (ΔVol) |
| CG_GG | 112; 38 | 23;13 | 463.5±15.8 | 1232.0±47.3 | 114.9±5.7 | |
| GNB3-rs10849527 CC | 116 | 35 | 512.9±15.0 | 1213.9±55.7 | 124.4±6.8 | .0029 ↓ (ΔVol) |
| CT_ TT | 90; 18 | 22;5 | 456.6±17.8 | 1221.6±55.5 | 114.1±6.6 | |
| GNB3-rs3759348 CC | 116 | 32 | 508.3±16.9 | 1231.8±60.4 | 119.3±7.3 | .0156↓ (ΔVol) |
| CT_TT | 91; 17 | 25;5 | 454.2±16.2 | 1201.7±50.5 | 120.3±6.4 | |
| GNB3-rs4963517 CC | 67 | 20 | 449.7±22.6 | 1188.4±54.8 | 109.6±7.3 | .0288 ↑ (ΔVol) |
| CT_ TT | 116; 41 | 30; 12 | 504.4±13.5 | 1231.0±52.2 | 124.7±6.1 | |
| GNB3-rs1129649 TT | 99 | 24 | 521.5±18.8 | 1238.8±73.1 | 123.0±9.2 | .0021 ↑ (ΔVol) |
| CC_CT | 99;26 | 30;8 | 462.2±14.2 | 1203.7±45.4 | 117.9±5.5 | |
| GNB3-rs1047776 GG | 190 | 54 | 480.5±13.0 | 1205.8±42.6 | 116.1±4.3 | .0042 ↓ (Solid GE) |
| AG_AA | 34;0 | 8; 0 | 524.3±30.3 | 1294.6±105.0 | 151.7±26.0 | |
| GNB3-rs5440 GG | 51 | 19 | 452.8±26.5 | 1196.7±53.5 | 118.6±8.6 | All p>0.15 |
| AA_AG | 63;110 | 17; 26 | 500.2±13.0 | 1226.3±51.9 | 120.3±5.8 | |
| GNB3-rs5443 (C825T) CC | 108 | 29 | 500.4±17.6 | 1307.0±66.0 | 122.6±8.7 | All p>0.15 |
| CT_TT | 100;16 | 30;3 | 472.0±15.7 | 1138.4±42.3 | 117.7±5.4 | |
| FTO-rs9939609 AA | 48 | 17 | 508.0±20.1 | 1372.8±80.6 | 108.8±8.0 | .0075 ↑ (MTV) |
| TT_ AT | 73;10 | 16;29 | 480.3±14.7 | 1158.5±42.2 | 124.0±5.8 | |
| 5_HTTLPR LL | 70 | 23 | 478.9±19.5 | 1118.7±62.9 | 124.3±7.1 | .1059 ↑ (MTV) |
| LS_SS | 109; 45 | 29; 10 | 491.9±15.3 | 1275.4±48.6 | 117.2±6.4 | |
Δ Vol=difference between postprandial and fasting gastric volume,
MTV=maximum tolerated volume during nutrient drink test,
GE=gastric emptying
↑ = acceleration of gastric emptying rate or increased volume (MTV or Δ Vol),
↓ = delay in gastric emptying rate, or decreased volume
†
=for test of association of response with genotype categories from the ANCOVA (adjusting for age and gender); unless otherwise stated, p>0.15