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Effects of HDAC7 on the turnover of ataxin-7. A direct effect of HDAC7 was confirmed by siRNA knockdown, which increased ataxin-7 levels in both ataxin-7-10Q (1-266)- and ataxin-7-92Q (1-266)-transfected cultures compared with controls with nontargeted siRNA. GAPDH was used as a loading control. HDAC7 levels are indicated for each condition.
