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Pyrimidine salvage pathway. Selected fungi are capable of salvaging thymine from dTMP by a series of reactions catalyzed by (1) pyrimidine deoxynucleoside-2′-hydroxylase, (2) nucleoside hydrolase or phosphorylase, (3) T7H, (4) uracil-5-carboxylate decarboxylase (also named iso-orotate decarboxylase), and (5) uracil phosphoribosyltransferase. The resulting UMP is available for conversion to other nucleotides by standard reactions.
