Table 2.

Mean serum levels of sex hormones and SHBG by treatment group (n = 180)^§

Sex hormones	Placebo (n=89)	Estradiol (n=91)
	Mean (SD)†	Mean (SD)†	p-value*
Estrone (pg/ml)	48.1(42.0)	310.3(167.2)	<.0001
Estradiol (pg/ml)	14.7(6.3)	68.2(16.2)	<.0001
Free estradiol (pg/ml)	0.6(0.2)	1.6(0.6)	<.0001
Total testosterone (ng/dl)	22.3(9.0)	22.8(10.8)	0.72
Free testosterone (pg/ml)	4.1(1.8)	3.1(1.6)	0.0001
Androstenedione (pg/ml)	522(189)	492 (180)	<.0001
DHEA (ng/ml)	2.14(1.34)	1.77(0.78)	<.0001
SHBG (nmol/L)	36.5(18.2)	58.2(23.6)	<.0001

^§Of the total 216, 36 women had baseline but no ontrial hormone assessment, either due to drop-out or lack of sample.

^*P-values were from t-test for independent samples.

^†Mean (SD) of all follow-up measures.