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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2010 May 7;1801(8):878–886. doi: 10.1016/j.bbalip.2010.05.003

Figure 2. Amyloid Processing in Lipid Rafts.

Figure 2

Amyloid precursor protein (APP) cleavage by β- and γ-secretases occurs most efficiently in lipid rafts. Aβ binds to membranes with a preference for anonic lipid head groups and can be translocated into GM1-rich lipid rafts where Aβ undergos a conformational shift that disrupts membrane stability, promotes peptide-peptide interactions and Aβ oligomer formation.