Figure 2.—

Preservation of local (a) and distal (b) eQTL across tissues. The percentage of eQTL that were preserved across tissues at various LOD thresholds is depicted in adipose, brain, liver, and muscle tissue. The eQTL at LOD > 2.7, 4.3, and 6 of a tissue were screened for detection at LOD > 2.7 in their respective comparison tissues (sex and mouse crosses were combined). The percentage indicates the degree of replication of eQTL at LOD > 4.3 in one tissue that overlap in its comparison tissue at LOD > 2.7 over the total number of eQTL at LOD > 4.3 detected in the first tissue and vice versa. For example, for the local eQTL in cross I, ∼70% of the local eQTL found in adipose at LOD > 6 were detected in brain at LOD > 2.7. The bar graph reflects the eQTL at LOD > 4.3 of the adipose tissue as compared to the eQTL at LOD > 2.7 of the brain, liver, and muscle (brain compared to adipose, liver, and muscle; liver compared to adipose, brain, and muscle; and muscle compared to adipose, brain, and liver).