Table I.
Genes with the greatest average fold change in monkey PESCs compared with skin fibroblasts.
| Number | Affymetrix probe set ID | Gene name | Gene symbol | Gene expression fold change* |
||
|---|---|---|---|---|---|---|
| ORMES-22 | rPESC-2 | ORMES-9 | ||||
| 1 | MmuSTS.2862.1.S1_at | Secreted phosphoprotein 1 | SPP1 | 395 | 267 | 307 |
| 2 | MmuSTS.2285.1.S1_at | POU class 5 homeobox 1 | POU5F1 | 302 | 262 | 265 |
| 3 | MmugDNA.27729.1.S1_at | SRY (sex-determining region Y)-box 2 | SOX2 | 283 | 332 | 272 |
| 4 | MmugDNA.15267.1.S1_at | RNA-binding protein with multiple splicing 2 | RBPMS2 | 234 | 208 | 267 |
| 5 | MmugDNA.14543.1.S1_at | Leucine rich repeat neuronal 1 | LRRN1 | 185 | 166 | 178 |
| 6 | MmugDNA.33796.1.S1_s_at | Lin-28 homolog B | LIN28B | 176 | 210 | 179 |
| 7 | MmugDNA.32128.1.S1_at | Nanog homeobox | NANOG | 175 | 153 | 185 |
| 8 | MmugDNA.38382.1.S1_at | Hypothetical protein LOC696162 | LOC696162 | 173 | 292 | 368 |
| 9 | MmugDNA.35853.1.S1_at | Prominin 1 | PROM1 | 173 | 141 | 169 |
| 10 | MmugDNA.34153.1.S1_at | Claudin 6 | CLDN6 | 171 | 172 | 224 |
| 11 | MmuSTS.3557.1.S1_at | DNA (cytosine-5-)-methyltransferase 3 beta | DNMT3B | 170 | 200 | 188 |
| 12 | MmuSTS.3741.1.S1_at | Protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | PTPRZ1 | 155 | 220 | 135 |
| 13 | MmunewRS.875.1.S1_at | Neuroligin 4, Y-linked | NLGN4Y | 142 | 176 | 134 |
| 14 | MmuSTS.1929.1.S1_at | v-myc myelocytomatosis viral-related oncogene, neuroblastoma derived | MYCN | 127 | 109 | 102 |
| 15 | MmugDNA.17159.1.S1_s_at | Nuclear factor (erythroid-derived 2)-like 3 | NFE2L3 | 124 | 138 | 198 |
| 16 | MmuSTS.4813.1.S1_at | Gamma-aminobutyric acid A receptor, beta 3 | GABRB3 | 119 | 115 | 82 |
| 17 | MmugDNA.20743.1.S1_at | Fraser syndrome 1 | FRAS1 | 109 | 142 | 129 |
| 18 | MmugDNA.33563.1.S1_at | Similar to histone cluster 3, H2a | LOC693768 | 109 | 121 | 109 |
| 19 | MmuSTS.214.1.S1_at | Zic family member 3 | ZIC3 | 106 | 138 | 89 |
| 20 | MmugDNA.19659.1.S1_at | Interleukin 17 receptor D | IL17RD | 105 | 83 | 127 |
| 21 | MmugDNA.15717.1.S1_at | Putative neuronal cell adhesion molecule | PUNC | 103 | 73 | 77 |
| 22 | MmuSTS.4486.1.S1_at | Similar to SRY (sex-determining region Y)-box 3 | LOC696412 | 97 | 51 | 54 |
| 23 | MmuSTS.2870.1.S1_at | Epithelial cell adhesion molecule | EPCAM | 96 | 155 | 156 |
| 24 | MmuSTS.4090.1.S1_at | Left-right determination factor 2 | LEFTY2 | 96 | 55 | 165 |
| 25 | MmugDNA.42677.1.S1_at | Similar to developmental pluripotency associated 4 | LOC706631 | 95 | 116 | 109 |
| 26 | MmugDNA.17017.1.S1_at | Orthodenticle homeobox 2 | OTX2 | 93 | 158 | 125 |
| 27 | MmugDNA.31410.1.S1_at | Hypothetical protein LOC722607 | LOC722607 | 92 | 109 | 163 |
| 28 | MmugDNA.35790.1.S1_at | Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 | SLC7A3 | 90 | 138 | 144 |
| 29 | MmugDNA.12610.1.S1_at | CD200 molecule | CD200 | 89 | 89 | 96 |
| 30 | MmugDNA.14842.1.S1_at | Cysteine-rich secretory protein LCCL domain containing 1 | CRISPLD1 | 85 | 60 | 62 |
| 31 | MmuSTS.1323.1.S1_at | Similar to desmoplakin isoform II | LOC694860 | 78 | 119 | 140 |
| 32 | MmugDNA.33242.1.S1_at | Podocalyxin-like | PODXL | 78 | 109 | 99 |
| 33 | MmugDNA.30027.1.S1_at | KIAA0746 protein | KIAA0746 | 77 | 79 | 53 |
| 34 | MmugDNA.10115.1.S1_at | Activin A receptor, type IIB | ACVR2B | 76 | 102 | 85 |
| 35 | MmugDNA.41979.1.S1_at | Sortilin-related receptor, L(DLR class) A repeats-containing | SORL1 | 75 | 74 | 90 |
| 36 | MmugDNA.21032.1.S1_at | Actin-binding LIM protein 1 | ABLIM1 | 75 | 70 | 71 |
| 37 | MmugDNA.13233.1.S1_at | Brain expressed X-linked 2 | BEX2 | 71 | 77 | 79 |
| 38 | MmugDNA.14104.1.S1_at | Protein phosphatase 1, regulatory (inhibitor) subunit 1A | PPP1R1A | 67 | 65 | 66 |
| 39 | MmugDNA.42748.1.S1_at | Chromosome 9 open reading frame 58 | C9ORF58 | 64 | 85 | 61 |
| 40 | MmuSTS.3925.1.S1_at | Similar to sal-like 2 | LOC708367 | 59 | 69 | 69 |
| 41 | MmuSTS.1436.1.S1_at | Similar to proto-oncogene tyrosine-protein kinase LCK (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) | LOC717810 | 55 | 64 | 111 |
| 42 | MmugDNA.16646.1.S1_at | Par-6 partitioning defective 6 homolog beta | PARD6B | 52 | 59 | 70 |
| 43 | MmugDNA.29316.1.S1_at | Chromodomain helicase DNA binding protein 7 | CHD7 | 51 | 61 | 58 |
| 44 | MmugDNA.36148.1.S1_at | Cytochrome P450, family 26, subfamily A, polypeptide 1 | CYP26A1 | 50 | 62 | 75 |
| 45 | MmugDNA.21560.1.S1_s_at | CD24 molecule | CD24 | 49 | 73 | 56 |
| 46 | MmuSTS.3354.1.S1_at | Hypothetical protein LOC697860 | LOC697860 | 49 | 66 | 55 |
| 47 | MmugDNA.31898.1.S1_s_at | Apolipoprotein E | APOE | 49 | 55 | 75 |
| 48 | MmugDNA.1925.1.S1_at | Similar to frizzled 5 | LOC710796 | 48 | 86 | 83 |
| 49 | MmugDNA.14234.1.S1_at | Cyclin D2 | CCND2 | 48 | 52 | 52 |
| 50 | MmugDNA.18039.1.S1_at | DNA (cytosine-5-)-methyltransferase 3 alpha | DNMT3A | 41 | 41 | 43 |
Bold fonts represent known pluripotency genes. *The fold change was calculated for each stem cell line versus the level of expression for a particular gene in adult monkey skin fibroblasts. ORMES-9 and ORMES-22 represent Oregon Rhesus Macaque Embryonic Stem-9 and -22, respectively, and rPESC-2 represent rhesus parthenogenetic embryonic stem cell.