Table II.
Highly down-regulated genes in PESCs compared with ESC controls.
| Number | Affymetrix Probe Set ID | Gene name | Gene symbol | Gene expression fold change* |
|
|---|---|---|---|---|---|
| rPESC-2 (heterozygous parthenote) | ORMES-9 (homozygous parthenote) | ||||
| 1 | MmugDNA.26310.1.S1_at | Small nuclear ribonucleoprotein polypeptide N | SNRPN | 161 | 107 |
| 2 | Mmu.16433.2.S1_at | Collagen, type III, alpha 1 | COL3A1 | 25 | 29 |
| 3 | MmuSTS.1142.1.S1_at | Similar to pleiomorphic adenoma gene-like 1 isoform 2 | PLAGL1 | 17 | 18 |
| 4 | MmugDNA.12446.1.S1_at | Paternally expressed 3 | PEG3 | 14 | 15 |
| 5 | MmuSTS.1946.1.S1_at | Necdin | NDN | 14 | 14 |
| 6 | MmugDNA.38558.1.S1_at | Paternally expressed 10 | PEG10 | 13 | 13 |
| 7 | MmugDNA.36408.1.S1_at | Carbonic anhydrase III, muscle specific | CA3 | 6 | 9 |
| 8 | MmuSTS.1960.1.S1_at | Forkhead box D1 | FOXD1 | 8 | 8 |
| 9 | MmugDNA.23547.1.S1_at | Sorting nexin 5 | SNX5 | 8 | 7 |
| 10 | MmugDNA.21169.1.S1_at | Similar to chondroitin beta1,4 N-acetylgalactosaminyltransferase 2 | LOC703703 | 7 | 8 |
| 11 | MmugDNA.19752.1.S1_at | Forkhead box F2 | FOXF2 | 8 | 6 |
| 12 | MmugDNA.11688.1.S1_at | Chromosome 3 open reading frame 52 | C3ORF52 | 5 | 5 |
| 13 | MmugDNA.1188.1.S1_at | GNAS1 antisense | NESPAS | 4 | 5 |
| 14 | MmugDNA.15601.1.S1_at | Methyltransferase 10 domain containing | METT10D | 4 | 5 |
| 15 | MmugDNA.40734.1.S1_at | Actin, alpha, cardiac muscle 1 | ACTC1 | 4 | 5 |
| 16 | MmugDNA.3198.1.S1_at | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | SERPINE1 | 4 | 5 |
| 17 | MmugDNA.42888.1.S1_at | Insulin-like growth factor binding protein 5 | IGFBP5 | 4 | 4 |
| 18 | MmugDNA.35544.1.S1_at | Nucleosome assembly protein 1-like 5 | NAP1L5 | 4 | 4 |
| 19 | MmugDNA.35385.1.S1_at | Homeobox D4 | HOXD4 | 4 | 4 |
| 20 | MmugDNA.33494.1.S1_at | Similar to ELAV-like 2 isoform 3 | LOC708195 | 5 | 3 |
| 21 | MmugDNA.10922.1.S1_at | Inositol polyphosphate-5-phosphatase F | INPP5F | 4 | 4 |
| 22 | MmugDNA.31587.1.S1_at | Protein tyrosine phosphatase, receptor type B | PTPRB | 4 | 4 |
| 23 | MmugDNA.29862.1.S1_at | Centrosomal protein 68 kDa | CEP68 | 4 | 3 |
| 24 | MmuSTS.1453.1.S1_at | MAGE-like 2 | MAGEL2 | 3 | 3 |
| 25 | MmugDNA.17878.1.S1 at | Transmembrane 4 L Six family member 19 | TM4SF19 | 3 | 3 |
Bold fonts are known paternally expressed imprinted genes. *The fold change (decrease) was calculated for PESCs versus the level of expression for a particular gene in the conventionally derived ORMES-22. ORMES-9 and ORMES-22 represent Oregon Rhesus Macaque Embryonic Stem-9 and -22, respectively and rPESC-2 represent rhesus parthenogenetic embryonic stem cell.