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. 2010 Jun 17;4:35. doi: 10.3389/fnins.2010.00035

Figure 1.

Figure 1

Regulation of 5-HT1A receptors in depression. Shown figuratively are 5-HT1A-expressing presynaptic raphe neuron and post-synaptic prefrontal cortical neuron. The 5-HT1A gene and its regulators (Deaf1, Freud-1, Freud-2, REST, Hes) are shown; 5-HT1A receptors (circle/triangle) and serotonin (triangles) are shown to indicate expected changes in their levels in depression. In depression, 5-HT1A receptor RNA and protein levels are increased presynaptically, leading to inhibition of 5-HT neurons (red-) and reduced firing. Paradoxically, the presynaptic levels of repressors REST and Deaf1 are increased, and there is also a trend for increase in Freud-1, perhaps to compensate for 5-HT1A overexpression due to the G(−1019) allele, for example. Post-synaptically, 5-HT1A receptors appear reduced, and levels of Deaf1 are also lower, although Freud-1 and Freud-2 (trend) increase. See text for details and references.