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Modulation of TIMP1 affects ovulation. Luteinized unruptured follicle syndrome was found in both Endo rats (A) and Sham rats treated with TIMP1 (B) but not in Sham rats (C). This is indicative of ovulatory dysfunction associated with excessive TIMP1. Corpora lutea (CL), follicles with granulosa cells (GC), and luteinized unruptured follicles (LUF) are noted. Original magnification ×200.
