Figure 7. Electroretinogram (ERG) reveals reduced b-wave amplitude in the LRP5 loss-of-function mutant mice.

7-week-old LRP5^r18 littermates including 3 heterozygous control (r18/+) and 5 homozygous mutant (r18/r18) were recorded. The results were collected by an Espion visual testing system (Diagnosys), and average amplitude value is shown for both control and mutant groups. Note a reduction of b-wave amplitude with light stimulation intensity from 0.01–3.16 cd.s/m², while no obvious reduction of a-wave amplitude was observed.