Table 2.

Mammography performance measures and the adjusted odds ratios comparing screening mammograms with a self-reported biopsy history to screening mammograms without a self-reported biopsy history^*

Mammography performance measures	Unadjusted measures (95% CI)			Adjusted OR
	No biopsy	Biopsy	Difference between no biopsy and biopsy (95% CI of difference)	OR* (95% CI)	P†
Sensitivity	82.3 (81.4 to 83.2)	79.6 (77.7 to 81.4)	2.70 (0.7 to 4.75)	0.88‡ (0.77 to 1.01)	.0597
Specificity	91.9 (91.8 to 91.9)	89.5 (89.4 to 89.6)	2.30 (2.21 to 2.45)	0.74§ (0.73 to 0.75)	<.0001
PPV1	4.1 (4 to 4.2)	4.7 (4.5 to 4.9)	−0.60 (−0.86 to −0.36)	1.01║ (0.95 to 1.07)	.8213
PPV2	25.4 (24.8 to 26.1)	25.4 (24.2 to 26.7)	0.02 (−1.34 to 1.38)	0.85¶ (0.79 to 0.92)	<.0001

^*Odds ratios (ORs) and 95% confidence intervals (CIs) for a correct interpretation comparing screening mammograms with a self-reported biopsy history with screening mammograms without a self-reported biopsy history were computed from multivariable logistic regression models including age at mammogram (in 5-year intervals), months since last mammogram, breast density, availability of comparison film, mammography registry, and year of examination as covariates. Examinations not associated with a biopsy history (no biopsy) were the referent group and included 1 714 281 screens (7181 screens were associated with subsequent breast cancer). A total of 293 100 screening mammograms with a self-reported biopsy history were also included (1884 screens were associated with subsequent breast cancer). PPV1 = positive predictive value 1; PPV2 = positive predictive value 2.

^†Two-sided P values for overall association of biopsy history with mammography performance measure, calculated using likelihood ratio tests.

^‡Odds of a positive screen (Breast Imaging Reporting and Data System [BI-RADS] = 0, 4, 5, or 3 with recommendation for additional evaluation) among screening mammograms from women with a subsequent cancer diagnosis (sensitivity), comparing screening mammograms from women with a biopsy history with screening mammograms from women without a biopsy history.

^§Odds of a negative screen (BI-RADS assessment = 1, 2, or 3 without recommendation for additional evaluation) among screening mammograms from women without a subsequent cancer diagnosis (specificity), comparing screening mammograms from women with a biopsy history with screening mammograms from women without a biopsy history.

^║Odds of a subsequent cancer among positive screening mammograms (BI-RADS = 0, 4, 5, or 3 with immediate work-up) (PPV1), comparing screening mammograms from women with a biopsy history with screening mammograms from women without a biopsy history.

^¶Odds of a subsequent cancer among screening mammograms with a recommendation for biopsy (BI-RADS = 4 or 5) (PPV2), comparing screening mammograms from women with a biopsy history with screening mammograms from women without a biopsy history.