Table 3.
Acute hematologic toxicity
| Training Cohort n (%) | Validation Cohort n (%) | p | Combined Cohort n (%) | |
|---|---|---|---|---|
| Leukopenia | 0.02* | |||
| Grade 0 | 9 (24) | 2 (5) | 11 (14) | |
| Grade 1 | 7 (19) | 4 (9) | 11 (14) | |
| Grade 2 | 13 (35) | 19 (43) | 32 (40) | |
| Grade 3 | 8 (22) | 16 (36) | 24 (30) | |
| Grade 4 | 0 (0) | 3 (7) | 3 (4) | |
| Neutropenia | 0.20 | |||
| Grade 0 | 19 (51) | 12 (27) | 31 (38) | |
| Grade 1 | 4 (11) | 7 (16) | 11 (14) | |
| Grade 2 | 10 (27) | 16 (36) | 26 (32) | |
| Grade 3 | 4 (11) | 7 (16) | 11 (14) | |
| Grade 4 | 0 (0) | 2 (5) | 2 (2) | |
| Anemia | 0.18 | |||
| Grade 0 | 9 (24) | 11 (25) | 20 (25) | |
| Grade 1 | 20 (54) | 16 (36) | 36 (44) | |
| Grade 2 | 6 (16) | 16 (36) | 22 (27) | |
| Grade 3 | 2 (5) | 1 (2) | 3 (4) | |
| Grade 4 | 0 (0) | 0 (0) | 0 (0) | |
| Thrombocytopenia | 0.48 | |||
| Grade 0 | 33 (89) | 36 (82) | 69 (85) | |
| Grade 1 | 3 (8) | 4 (9) | 7 (9) | |
| Grade 2 | 1 (3) | 4 (9) | 5 (6) | |
| Grade 3 | 0 (0) | 0 (0) | 0 (0) | |
| Grade 4 | 0 (0) | 0 (0) | 0 (0) |
*
statistically significant