Table 6.
Generalized linear model of hematologic nadirs as a function of dosimetric parameters in the combined cohort
| log (WBC Nadir) (k/μL) |
log (ANC Nadir) (k/μL) |
HGB Nadir (g/dL) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| β | 95% CI | p | β | 95% CI | p | β | 95% CI | p | |
| V10 | −0.022 | −0.04, −0.003 | 0.025* | −0.029 | −0.05, −0.005 | 0.019* | −0.054 | −0.12, 0.01 | 0.094 |
| V20 | −0.021 | −0.03, −0.01 | 0.002* | −0.027 | −0.04, −0.01 | 0.001* | −0.053 | −0.10, −0.01 | 0.016* |
| V30 | −0.011 | −0.02, −0.0001 | 0.048* | −0.014 | −0.03, 0.001 | 0.034* | −0.020 | −0.06, 0.02 | 0.256 |
| V40 | −0.008 | −0.02, 0.003 | 0.143 | −0.011 | −0.02, 0.001 | 0.069 | −0.007 | −0.04, 0.03 | 0.689 |
| Mean Dose | −0.350 | −0.07, −003 | 0.033* | −0.043 | −0.08, −0.004 | 0.030* | −0.069 | −0.17, 0.03 | 0.189 |
CI: confidence interval; WBC: white blood cell count; ANC: absolute neutrophil count; HGB: hemoglobin; β: regression coefficient. Note: coefficients adjusted for effect of log(body mass index).
statistically significant