Figure 5.

Kal7 is essential for formation of cocaine place preference. In a conditioned place preference test carried out on the schedule indicated, mice of both genotypes exhibited a significant preference for the cocaine-paired side, with the response of Kal7^KO mice substantially attenuated compared to littermate controls at both 10 and 20mg/kg cocaine (Middle; p=0.025 for 10mg/kg; p=0.029 for 20mg/kg). When food was used as the unconditioned stimulus, both genotypes formed an equal preference for the food paired chamber (Right; p=0.64) indicating that the difference between Wt and Kal7^KO mice was specific to drug preference. Animals injected with saline only did not form a preference for either chamber (Left). (*p<0.05; **p<0.01 ANOVA) [N=6-10/group].