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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Biol Psychiatry. 2010 Jun 8;68(3):256–264. doi: 10.1016/j.biopsych.2010.04.016

Figure 1.

Figure 1

PPARα blockade activates VTA dopamine neurons in vitro. (A) MK886 application (0.5 µM) increases dopamine neuron spontaneous activity. Current-clamp recording from a dopamine neuron (left panel) and rate histogram depicting MK886 averaged effects (right panel). (B) In voltage-clamp mode MK886 caused an inward current (Vhold= −70 mV) blocked by the PPARα agonist WY14643 (0.3 µM). (C) WY14643 blocked MK886-induced activation of dopamine neurons. (D) Summary of dose-related effects of PPARα antagonists on dopamine neuronal frequency. Numbers above bars indicate n values. Data expressed as mean ± SEM. *p < 0.05; **p < 0.005.