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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Biol Psychiatry. 2010 Jun 8;68(3):256–264. doi: 10.1016/j.biopsych.2010.04.016

Figure 6.

Figure 6

PPARα activation reduces VTA output and nicotine induced stimulation of locomotion. (A and B). Typical evoked field potential recordings showing effects of MK886 (0.5 µM, A) and WY14643 (1 µM, B) on field potential amplitude. Bin= 10 s. Traces from typical experiments (top), time-courses of the effects of MK886 and WY14643 on N1 (middle) and N2 (bottom) components, and the mean averaged responses (bar graph in insets) are shown. (C) Averaged N2 amplitude from the VTA of β2−/−, β2+/+ and β2-DA-VEC mice in response to WY14643 (1 µM). Bin= 1 min. (D) WY14643 (40 mg/kg i.p.) decreases the number of VTA DA cells encountered during neuronal sampling in anesthetized rats (left panel), but not averaged firing frequency (right panel). (E) Time-course curve of nicotine (0.02 mg/kg, s.c.) effects on locomotor activity in WY14643- and vehicle- treated mice. (F) Time-course curve of nicotine (0.02 mg/kg, s.c.) effects on locomotor activity in WY14643- and vehicle- treated β2-DA-VEC mice compared with β2−/− mice. Arrows indicate time of nicotine administration. Data expressed as mean ± SEM. *p < 0.05.