Table 2.
Summary of antifungal susceptibility values by species determined by CLSI and agar dilution methods.
| Method |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Agar Dilution | CLSI | No. of categorical errors | % Categorical error | ||||||||||
| Antifungal agent | Organism (n) | MIC min | MIC max | MIC 50 | MIC 90 | S | R* | S | R* | ME | VME | ME | VME |
| Anidulafungin | C. albicans (20) | ≤0.03 | 1 | ≤0.03 | ≤0.03 | 20 | 0 | 20 | 0 | 0 | 0 | 0 | 0 |
| Anidulafungin | C. dubliniensis (1) | ≤0.03 | ≤0.03 | ≤0.03 | ≤0.03 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Anidulafungin | C. glabrata (29) | ≤0.03 | >16 | ≤0.03 | 1 | 23 | 6 | 23 | 6 | 1 | 1 | 4 | 17 |
| Anidulafungin | C. guilliermondii (5) | 0.125 | 1 | 0.125 | 1 | 3 | 2 | 3 | 2 | 0 | 0 | 0 | 0 |
| Anidulafungin | C. lusitaniae (2) | ≤0.03 | ≤0.03 | ≤0.03 | ≤0.03 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| Anidulafungin | C. parapsilosis (19) | 0.125 | 0.5 | 0.25 | 0.5 | 18 | 1 | 19 | 0 | 1 | 0 | 5 | 0 |
| Anidulafungin | C. rugosa (2) | ≤0.03 | 2 | ≤0.03 | 2 | 2 | 0 | 1 | 1 | 0 | 1 | 0 | 100 |
| Anidulafungin | C. tropicalis (7) | ≤0.03 | 2 | ≤0.03 | 2 | 6 | 1 | 6 | 1 | 0 | 0 | 0 | 0 |
| Anidulafungin | Candida spp. (5) | 0.125 | 4 | 1 | 4 | 2 | 3 | 2 | 3 | 0 | 0 | 0 | 0 |
| Caspofungin | C. albicans (22) | <0.03 | >16 | 0.06 | 0.125 | 21 | 1 | 21 | 1 | 0 | 0 | 0 | 0 |
| Caspofungin | C. dubliniensis (1) | <0.03 | <0.03 | <0.03 | <0.03 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Caspofungin | C. glabrata (30) | <0.03 | >16 | 0.25 | >16 | 26 | 4 | 17 | 13 | 0 | 9 | 0 | 69 |
| Caspofungin | C. guilliermondii (5) | 2 | 16 | 16 | 16 | 3 | 2 | 0 | 5 | 0 | 3 | 0 | 60 |
| Caspofungin | C. lusitaniae (2) | 0.06 | 0.125 | 0.06 | 0.125 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| Caspofungin | C. parapsilosis (19) | 0.125 | 2 | 0.25 | 0.5 | 15 | 4 | 18 | 1 | 4 | 1 | 22 | 100 |
| Caspofungin | C. rugosa (2) | 16 | 16 | 16 | 16 | 2 | 0 | 0 | 2 | 0 | 2 | 0 | 100 |
| Caspofungin | C. tropicalis (8) | <0.03 | >16 | <0.03 | >16 | 7 | 1 | 7 | 1 | 0 | 0 | 0 | 0 |
| Caspofungin | Candida spp. (5) | 0.25 | >16 | 2 | >16 | 1 | 4 | 1 | 4 | 0 | 0 | 0 | 0 |
| Micafungin | C. albicans (20) | ≤0.03 | 2 | ≤0.03 | 0.25 | 19 | 1 | 19 | 1 | 0 | 0 | 0 | 0 |
| Micafungin | C. dubliniensis (1) | ≤0.03 | ≤0.03 | ≤0.03 | ≤0.03 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Micafungin | C. glabrata (30) | ≤0.03 | >16 | ≤0.03 | 4 | 26 | 4 | 24 | 6 | 0 | 2 | 0 | 33 |
| Micafungin | C. guilliermondii (5) | 0.125 | 0.5 | 0.25 | 0.5 | 5 | 0 | 5 | 0 | 0 | 0 | 0 | 0 |
| Micafungin | C. lusitaniae (2) | ≤0.03 | ≤0.03 | ≤0.03 | ≤0.03 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| Micafungin | C. parapsilosis (19) | 0.25 | 0.5 | 0.5 | 0.5 | 19 | 0 | 19 | 0 | 0 | 0 | 0 | 0 |
| Micafungin | C. rugosa (2) | ≤0.03 | 16 | ≤0.03 | 16 | 2 | 0 | 1 | 1 | 0 | 1 | 0 | 100 |
| Micafungin | C. tropicalis (7) | ≤0.03 | 16 | ≤0.03 | 16 | 7 | 0 | 6 | 1 | 0 | 1 | 0 | 100 |
| Micafungin | Candida spp. (5) | 0.5 | 8 | 2 | 8 | 2 | 3 | 1 | 4 | 0 | 1 | 0 | 25 |
*
R = notation of resistant or non-susceptible.